Case studies

Statin-associated muscle adverse events: some key issues explored

Leon A Simons


Muscle symptoms and signs often represent an important adverse event associated with statin therapy.

Key Points

  • Muscle symptoms and signs are the most frequent adverse events associated with statin therapy.
  • These adverse events occur more frequently in routine care than in controlled clinical trials.
  • Alternative causes must be excluded.
  • Less frequent-than-daily dosing with another statin at a low dose may overcome muscle problems in some instances.

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