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Case studies
A patient with familial hypercholesterolaemia unable to achieve target LDL-cholesterol levels
Recent articles on:
Lipid disorders
Lipid disorders
Abstract
Without treatment, a man with heterozygous familial hypercholesterolaemia has a 51% chance of presenting with coronary disease by age 50 years and a woman has a 58% chance by age 60 years.
Key Points
- Patients with heterozygous familial hypercholesterolaemia (FH) have a high risk of manifesting with premature coronary disease.
- Treatment with statins (and other standard cardiovascular medications) is likely to be beneficial.
- Multiple lipid-regulating drugs may not achieve target LDL-cholesterol readings in patients with FH, but a 50% reduction in LDL-cholesterol levels is acknowledged as an acceptable secondary goal.
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